Serine and one-carbon metabolism in cancer

By Ming Yang, Karen H. Vousden. Nature Reviews. Cancer, 2016

906 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/52df71256e3fb907b31a6ff031f20d84d6690fa7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Dinkova-Kostova
2. C. V. Dang

In Cancer Research

1. C. V. Dang
2. Ping Gao
3. Huafeng Zhang
4. P. Vaupel
5. Gabriele Multhoff
6. A. Dinkova-Kostova
7. J. Hayes
8. K. Tew

In Molecular Biology

1. A. Dinkova-Kostova
2. Ping Gao
3. Huafeng Zhang
4. C. V. Dang
5. Linchong Sun
6. P. Vaupel
7. J. Hayes
8. B. Altman

Citations in the corpus

• Revisiting the Warburg effect: historical dogma versus current understanding (2020, background): “(c) The non-essential amino acids serine and glycine and the one-carbon metabolism pathway emanate from the intermediate 3-phosphoglycerate (Yang & Vousden, 2016).”
• Oxidative Stress in Cancer (2020, background): “glycine (from serine by serine hydroxymethyltransferase within the one-carbon pathway) and cysteine (from cystathionine by cystathionine lyase within the trans-sulfuration pathway), two of the amino acids used to synthesize GSH (Yang and Vousden, 2016); the supply of cysteine can be augmented by the”
• NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism (2018, background): “In addition, other enzymes also contribute to the cytosolic NADPH pool, such as IDHs and MEs (87, 139), all of which have both cytosolic and mitochondrial isozymes.”
• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “2). me-THF can also be produced by the glycine cleavage system (glycine dehydrogenase (GLDC) is the major component), in which glycine is cleaved into ammonia, carbon dioxide, and a carbon © The Author(s) 2021 887 P ro te in & C e ll unit, which is involved in the methylation of THF (Locasale, 2013;”
• Revisiting the hallmarks of cancer. (2017, neutral): “The acquisition of lipids or fatty acids, amino acids other than glutamine, and extracellular acetate, and their contribution and necessity to tumorigenesis are subjects of recent research [144, 155-157].”
• From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy (2016, background): “BPTES inhibition of hGA(124-551), a truncated form of human kidneytype glutaminase.”