A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

By H. Masuzaki, J. Paterson, H. Shinyama, N. Morton, J. Mullins, J. Seckl, J. Flier. Science, 2001

1,876 citations recorded by the source corpus.

Subfields: Cell Biology, Endocrinology, Diabetes and Metabolism, Pharmacology

View Paper: https://www.semanticscholar.org/paper/5178305d0dc4a7465d735ad0280290410cff5289

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Citations in the corpus

An integrative genomics approach to infer causal associations between gene expression and disease (2005, background): “The association of Hsd11b1 with the OFPM trait was previously established in a transgenic mouse overexpressing Hsd11b1 in adipose tissu”
Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. (2009, background): “Overactivity of 11 -HSD1 is associated with enhanced expression of GRa in adipose tissue and increased intracellular conversion of cortisone to cortisol (121, 122).”
Fructose, weight gain, and the insulin resistance syndrome. (2002, background): “Increased expression of this enzyme, specifically in adipose tissue, was shown recently to induce visceral obesity, insulin-resistant diabetes, and hyperlipidemia in a transgenic mouse model (13).”
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. (2007, background): “…likely driven by increased activity of 11b-hydroxysteroid dehydrogenase type 1, which converts inactive cortisone into active cortisol—causes insulin resistance in rodents and may contribute to the development of the disease in humans (Kotelevtsev et al., 1997, 1999; Masuzaki et al., 2001, 2003).”
Developmental origin of fat: tracking obesity to its source. (2007, positive): “For example, transgenic mice overexpressing 11-β hydroxysteroid dehydrogenase in fat have the same level of enzyme in various fat depots but develop only visceral obesity (Masuzaki et al., 2001).”
Obesity and the role of adipose tissue in inflammation and metabolism. (2006, neutral): “pression, hyperphagia, hyperlipidemia, and hypertension (64).”
The Human Obesity Gene Map: The 2005 Update (2006, neutral): “Promoter aP2-specific expression Increased adiposity (426)”
Reversal of obesity by targeted ablation of adipose tissue (2004, background): “Obesity is associated with increased risk for diabetes mellitus, cancer and heart disease, and it often causes shortening of human lif”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Transgenic overexpression of 11 HSD1 selectively in mouse adipose tissue produces a syndrome of visceral obesity, insulin resistance, and diabetes (Masuzaki et al. 2001), suggesting that increases in endogenous 11 -HSD1 that have been observed in adipose tissue of obese humans and rodents (Livingsto”