Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

By Zhenyu Yue, Shengkan Jin, Ching-Pa Yang, Arnold J. Levine, N. Heintz. Proceedings of the National Academy of Sciences of the United States of America, 2003

2,229 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/51525a9c8be7e63f959ac2bfa3158f9db5b10d7c

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Citations in the corpus

Molecular definitions of autophagy and related processes (2017, neutral): “…caused in mice by the genetic ablation of any of these components of the macroautophagy machinery at the whole-body level (Qu et al , 2003; Yue et al , 2003; Kuma et al , 2004; Komatsu et al , 2005; Gan et al , 2006; Saitoh et al , 2008, 2009; Sou et al , 2008), which is likely to reflect…”
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. (2007, background): “in the coordinate activation of apoptosis and autophagy (22), and both processes have been shown to provide tumor suppressor activity (21, 24, 25).”
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “Knockout mice lacking Beclin-1 (Bcn1 / ) die during embryogenesis (Qu et al., 2003; Yue et al., 2003).”
Autophagy suppresses tumor progression by limiting chromosomal instability. (2007, background): “…in tumorigenesis, as haploinsuffieciency in the essential autophagy gene beclin1 is commonly observed in sporadic human ovarian, breast, and prostate cancers (Aita et al. 1999), and allelic loss of beclin1 promotes the incidence of sporadic malignancies in mice (Qu et al. 2003; Yue et al. 2003).”
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “Studies in mice have demonstrated that monoallelic deletion of beclin-1 increases the frequency of spontaneous malignancies including hepatocellular carcinoma, B cell lymphoma and lung adenocarcinomas in beclin-1 +/- mice, suggesting beclin-1 as a haploinsufficent tumor suppressor gene [148].”
The Roles of Autophagy in Cancer (2018, background): “In cancer-cell lines and mice models, the loss of BECN1 results in a reduction of autophagy and an increase in cell proliferation, further indicating that BECN1 gene acts as a tumor suppressor [44,53,54].”
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1- phosphatidylinositol 3-kinase complex (2009, neutral): “Figure 5 Overexpressed Rubicon is localized on PI(3)P-enriched structures in a Beclin 1-independent manner.”
Autophagy: dual roles in life and death? (2005, background): “Importantly, one allele of the autophagy gene Atg6 is deleted in several forms of human cancer, and Atg6 -knockout mice that are heterozygous mutant have epithelial and haematopoietic malignancie”
Autophagy-deficient mice develop multiple liver tumors. (2011, background): “Mice with heterozygous disruption of Beclin 1, the mammalian homolog of yeast Atg6, induce an increased frequency of spontaneous cancers, lung cancers, hepatocellular carcinomas, and lymphomas (Qu et al. 2003; Yue et al. 2003).”