Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
By L. Monney, C. A. Sabatos, J. L. Gaglia, Akemi Ryu, H. Waldner, T. Chernova, Stephen Manning, E. Greenfield, A. Coyle, R. Sobel and 2 more. Nature, 2002
1,666 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/51053d3e3b45da3ce63929dd03d5d9f7e3498d58
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In Immunology
- D. Pardoll
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- G. Freeman
- Rafi Ahmed
- S. Topalian
- V. Kuchroo
- G. Dranoff
- Charles G. Drake
Citations in the corpus
- Immunology of multiple sclerosis. (2005, neutral): “Even though inflammation decreases during SP-MS (Figure 1), the secretion of proinflammatory cytokines IL-12, IL-18, and IFN-γ are elevated during later stages (176, 177), the activation of Th1 cells is less strictly controlled, and Th1 markers CCR5 and TIM-3 are upregulated (178, 179).”
- Alternative activation of macrophages (2003, background): “Contact-dependent interactions between T cells and macrophages are poorly defined still, but they are known to modulate macrophage activity directly, as well as through cytokine”
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (2010, background): “Tim-3 is a molecule originally identified as being selectively expressed on IFN- –secreting Th1 and Tc1 cells (Monney et al., 2002).”
- Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin1 (2007, methodology): “The relative quantities of the gene tested per sample were calculated against 36B4 using the delta delta threshold cycle ( Ct) formula as previously described (7).”
- TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity (2010, background): “In vivo treatment with TIM-3 mAb during the induction of EAE accelerated disease progression and resulted in a severe form of demyelinating disease characterized by higher numbers of inflammatory foci in the central nervous system (CNS) and higher numbers of activated macrophages in demyelinating le”
- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients (2010, background): “Tim-3 is a transmembrane protein constitutively expressed on Th1/Tc1 cells in mice and humans (Monney et al., 2002).”