Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

By P. Tomasec, V. Braud, C. Rickards, Martin B. Powell, Brian P Mcsharry, S. Gadola, V. Cerundolo, L. Borysiewicz, A. McMichael, G. Wilkinson. Science, 2000

711 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/50be8df62d50daac11672921e0a963a2d23b168d

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In Molecular Biology

1. E. Latz
2. L. Lanier

Citations in the corpus

• Viral mechanisms of immune evasion (2000, neutral): “In addition, the HCMV UL40 protein provides a peptide selectively required for the maturation of the HLA-E molecule, an NK target 39, 40 .”
• Natural killer cells, viruses and cancer (2001, background): “Another HCMV gene, UL40 , has been proposed as a candidate to subvert NK cell immune response”
• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “At least four gene products interfere with major histocompatibility complex class I antigen presentation (16, 58), and two CMV-encoded proteins interact with HLA-E, which leads to suppression of NK responses and protection from NK-mediated lysis (12, 54, 57).”
• Modulation of natural killer cell activity by viruses (2010, neutral): “To account for this HCMV encodes gpUL40 whose leader sequence is identical to leader sequences of classical MHC I molecules [17,18].”