Viral mechanisms of immune evasion
By A. Alcamí, U. Koszinowski. Immunology today (Amsterdam. Regular ed.), 2000
870 citations recorded by the source corpus.
During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus–host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.
Subfields: Animal Science and Zoology, Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/cc2e331d26a168d696a5e753ad492f66bab6b480
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Citations in the corpus
- Helminth parasites – masters of regulation (2004, background): “Viral pathogens devote a considerable portion of their compact genomes to immune evasion products with fascinating properties (201).”
- Bats: Important Reservoir Hosts of Emerging Viruses (2006, background): “Some commonly employed evasion strategies include virus-encoded immune-modulating cytokines, decoy soluble cytokine receptors, inhibitors of apoptosis and cellular signaling, inhibitors of antigen processing, and T-cell antagonists (2, 3, 18, 61, 70, 79, 87, 104, 150, 152).”
- Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “Later during the replication cycle, CMV encodes several chemokines and chemokine receptors that also provide potent inflammatory signals that are likely to contribute to pathogenesis as well (3, 34).”