The Neuropathology of Probable Alzheimer's Disease and Mild Cognitive Impairment

By Julie A. Schneider, Zoe Arvanitakis, Sue E. Leurgans, David A. Bennett. Annals of Neurology, 2009

936 citations recorded by the source corpus.

Mixed pathologies are common in older persons with dementia. Little is known about mixed pathologies in probable Alzheimer disease (AD) and about the spectrum of neuropathology in mild cognitive impairment (MCI). The objective of this study was to investigate single and mixed common age‐related neuropathologies in persons with probable AD and MCI.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/5050d12b5e95a3022643b288d856c27771947ed6

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Citations in the corpus

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers (2016, methodology): “Fourth, the prevalence of AD, non-AD, and mixed brain pathologies increases with age in both individuals who are clinically impaired and those nonimpaired.(20) To be an effective tool in cognitive aging research, a biomarker classification system must include all possible biomarker profiles and all ”
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (2012, neutral): “The current ability to estimate the relative contributions of AD or VBI to cognitive impairment in a given individual is limited [70–73].”
The pathobiology of vascular dementia (2013, neutral): “Furthermore, community-based clinical-pathological studies revealed that the largest proportion of dementia cases have mixed pathology, comprising features of AD (amyloid plaques and neurofibrillary tangles) as well as ischemic lesions (Launer et al., 2008; Schneider et al., 2009).”
Impact of multiple pathologies on the threshold for clinically overt dementia (2017, neutral): “Data from the ROS/MAP cohort showed about 50% of persons diagnosed with probable AD had mixed pathologies (AD, PD/LBD, or macroscopic infarcts), of which the most common is the presence of AD pathology and infarcts at 38% [111].”
Impact of Hypertension on Cognitive Function (2016, neutral): “Conversely, individuals with hypertension are also more likely to be categorized as having vascular or mixed dementia rather than “pure” AD, and this diagnostic bias could result in an apparent protective effect of hypertension on clinically diagnosed AD.”