A mutator phenotype in cancer.

By Lawrence Loeb. Cancer Research, 2001

832 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4fbb63b269edfe5112c1aca3cbbbdec6df28d817

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Citations in the corpus

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. (2002, background): “Activated oncogenes can induce ARF and sions engendering mutator phenotypes play an impor- contribute to premature senescence (Sherr and Weber, tant role in cancer progression (Loeb, 2001).”
Air pollution and public health: emerging hazards and improved understanding of risk (2015, background): “Oxidative stress is linked to several DNA lesions and the formation of bulky adducts—mechanisms by which traffic-related pollution could elicit mutagenesis and in turn cause cancer (Loeb 2001).”
Environmental and chemical carcinogenesis. (2004, background): “Measurements of mutagenesis of cells grown in culture yield values of approximately 2× 10−10 single base-substitutions/nucleotide in DNA/cell division or 1× 10−7 mutations gene/cell division [47].”
The role of necroptosis in cancer biology and therapy (2019, background): “The mechanisms underlying this seemingly paradoxical phenomenon may be related to the inflammatory response triggered by necroptosis, which may provide a tumor- promoting inflammatory microenvironment or elevated reactive oxygen species (ROS) production, which is correlated with genomic instability ”
Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “The normal human point mutation rate is 10−10 per base pair per cell division (Kunkel and Bebenek 2000), and this rate is elevated in many cancers, a phenomenon termed mutator phenotype (Loeb 2001; 2011).”
Genetic Progression and the Waiting Time to Cancer (2007, background): “However, it has also been argued that tumor cells have mutator phenotypes that accelerate the acquisition of mutations [14].”
Cancer as a metabolic disease (2010, background): “This paradox has remained largely unresolved [7].”
The changing faces of glutathione, a cellular protagonist. (2003, background): “Certain genetic alterations work as an instigator, facilitating the occurrence of sequential independent alterations at a significantly higher incidence (mutator phenotype) (Loeb, 2001).”