Role of integrins in cell invasion and migration

By J. Hood, D. Cheresh. Nature Reviews. Cancer, 2002

1,811 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4f06802b18f5189a605ab283c4ed3b7d5181815b

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Citations in the corpus

Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “Moreover, these downstream effector molecules in return have repercussions on the expression and function of cell surface molecules (‘inside-out’ signaling) (Hood and Cheresh, 2002; Stupack and Cheresh, 2002).”
α4β1- and α6β1-integrins are functional receptors for midkine, a heparin-binding growth factor (2004, background): “In MKdeficient mice, leukocyte infiltration into the blood vessels and kidney after ischemic injury is suppressed, leading to the suppression of neointima formation and nephritis after ischemia (Horiba et al., 2000; Sato et al., 2001).”
New signals from the invasive front (2006, background): “Role of integrins Integrins are heterodimeric cell-surface receptors that consist of two transmembrane subunits, α and β, which form distinct integrin subtypes linking extracellular matrix (ECM) ligands, such as fibronectin, vitronectin, laminin and collagen, to the intracellular actin cytoskele”
Therapeutic targeting of the tumor microenvironment. (2005, neutral): “Several integrins, including α v β 3, α v β 5, α 5 β 1, and α 6 β 4, are upregulated in cancer, and are expressed on endothelial cells, tumor cells, or both (Guo and Giancotti, 2004; Hood and Cheresh, 2002).”
Angiogenesis in brain tumours (2007, background): “Cell-matrix receptors such as the α v β 5 , α v β 3 and α 5 β 1 integrins mediate endothelial-cell spreading and migration in response to growth factor signallin”
Matrix metalloproteinases and tumor metastasis (2006, background): “These processes are mediated mainly by selectins for tumor cell/endothelial cell binding and by integrins for tumor cell/extracellular matrix interactions [176].”
Galectins as modulators of tumour progression (2005, background): “It has been extensively documented that loss of intercellular adhesion is correlated with tumour invasion and metastasi”
Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation (2010, background): “However, many cancer cells overexpress certain integrins to control migration, extravasation, and homing [70].”