Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

By Mitsuharu Sato, H. Suemori, N. Hata, M. Asagiri, K. Ogasawara, K. Nakao, T. Nakaya, M. Katsuki, S. Noguchi, N. Tanaka and 1 more. 2000

1,301 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury (2008, background): “Deletion of irf3 (Sato et al., 2000) did not show a significant change in acid-mediated ALI (Figures S2E and S2F).”
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 (2005, background): “Among them, IRF-3 is essential for the primary activation of IFN genes (4).”
Toll-like receptor signalling (2004, background): “Subsequently, both IRF3 and IRF7 are involved in the production of delayed-type IFNs (IFN-α/β), thereby amplifying the expression of IFN”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Mouse embryonic fibroblasts (MEFs) from both IRF-3 and IRF-7 mice show impaired induction of IFN-b (Sato et al., 2000; Honda et al., 2005b), indicating that, although neither factor is essential, both appear important in induction in these cells, although it remains uncertain whether the IRF7 effect”
TLR3: interferon induction by double-stranded RNA including poly(I:C). (2008, background): “Phosphoprylated IRF-3 translocates into the nucleus and induces IFN-β gene transcription [57].”
A Mouse Model of Zika Virus Pathogenesis (2016, neutral): “, 2010), Irf3 / (Sato et al., 2000), Irf5 / (Takaoka et al.”