RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

By A. Verdel, Songtao Jia, S. Gerber, T. Sugiyama, Steven P. Gygi, S. Grewal, D. Moazed. Science, 2004

1,311 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4e8560d838d07586272153758d1fc43d207d67bb

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Citations in the corpus

Perspective: machines for RNAi. (2005, background): “2002; Mochizuki et al. 2002; Volpe et al. 2002; Schramke and Allshire 2003; Liu et al. 2004b; Noma et al. 2004; Verdel et al. 2004).”
The promises and pitfalls of RNA-interference-based therapeutics (2009, unknown): “pombe , the process is mediated by the RNA-induced transcriptional silencing complex (RITS), which contains Ago1, the chromodomain protein Chp1 and the glycine and tryptophan (GW)-repeat-containing protein Tas3 (ref”
The rise of regulatory RNA (2014, background): “…74,250 , fungi 251 and human cells 88 , with an intimate involvement of small RNAs and the RNA interference pathway in the epigenetic processes involved 251–253 , consistent with the observation that small RNAs interact with Polycomb 254 and that Ago proteins occur in the nucleus 86,87 (Figure 3).”
DNA methylation and human disease (2005, background): “Recent evidence, primarily from fission yeast, indicates that the RNAi machinery (the RNA-induced initiation of transcriptional gene silencing (RITS) complex) directs elements of the repressive histone modification apparatus to regions destined for silencin”
MicroRNA control in the immune system: basic principles. (2009, background): “Silencing of centromeric repeats through such a mechanism has been demonstrated in yeast (Verdel et al., 2004; Volpe et al., 2002), and there was indeed an indication in Dicer-deficient B cells for a derepression of a set of D elements in the IgH locus, which exhibit a similar repeat structure…”