Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
By John B Davis, J. Gray, M. Gunthorpe, J. Hatcher, P. T. Davey, P. Overend, M. Harries, J. Latcham, Colin Clapham, Kirsty Atkinson and 9 more. Nature, 2000
1,746 citations recorded by the source corpus.
Subfields: Dermatology, Physiology, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/4e4a2f892c0e38d1aafa5e5311fb369c161f4373
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In Sensory Systems
Citations in the corpus
- TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “However, in contrast to phenotypes observed with TRPV1 À/À mice (Caterina et al., 2000; Davis et al., 2000), TRPA1 À/À animals exhibited robust thermal hypersensitivity when challenged with complete Freund's adjuvant, which activates multiple inflammatory pathways.”
- Trp ion channels and temperature sensation. (2006, background): “Similarly, mutations in various classes of proteins that cause deafness in mammals, and the complex anatomical structure of mammalian inner ear hair cells, also suggest the requirement for specialized structures for mechanosensation (Steel & Kros 2001, Hudspeth 2005).”
- Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide (2001, background): “Future studies with capsazepine (which antag- onizes capsaicin e ects in rats (Di Marzo et al., 2001) but not always in mice (Di Marzo et al., 2000b), and VR1 `knockout' mice (Davis et al., 2000; Caterina et al., 2000), should test the involvement of VR1 in the pharmacological actions of CBD.”
- TRP channels and pain. (2013, background): “…decrease this threshold, and genetic and pharmacologic studies have shown that TRPV1 is an essential component of the cellular signaling mechanisms through which injury produces thermal hyperalgesia and pain hypersensitivity (Basbaum et al. 2009, Caterina et al. 2000, Davis et al. 2000).”
- Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, background): “The complete heat pain insensitivity of mice lacking central TRPV1 fibers contrasts with the phenotype of Trpv1 knockout mice, which exhibit only a partial reduction in heat sensitivity (35, 36).”
- The vanilloid receptor: a molecular gateway to the pain pathway. (2001, background): “Indeed, the absence of statistically significant differences in heat-evoked responses between genotypes in the study by Davis & colleagues (Davis et al 2000) most likely stems from the relatively low noxious temperatures used in that study.”