Ubiquitin-Dependent And Independent Signals In Selective Autophagy.

By Aliaksandr Khaminets, C. Behl, Ivan Dikic. Trends in Cell Biology, 2016

663 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/4dbba4854c75df8862c78cf97d834ddda64bb843

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Alec C. Kimmelman
2. E. White
3. S. Gordon
4. R. Amaravadi
5. Guido Kroemer
6. Chang S. Chan
7. J. Mehnert
8. Y. Fouad

In Molecular Biology

1. Alec C. Kimmelman
2. Wenyi Wei
3. S. Gordon
4. Lei Chen
5. T. Meng
6. E. White
7. Ping Wang
8. Lu Deng

In Parasitology

1. E. White
2. Alec C. Kimmelman

Citations in the corpus

• Phagocytosis: An Immunobiologic Process. (2016, background): “…of intracellular components destined for selective autophagy (Herhaus and Dikic, 2015); various forms of ubiquitin conjugates interact with autophagy receptors such as optineurin, involving phosphorylation by TBK (Khaminets et al., 2016) and ER-phagy and turnover (Khaminets et al., 2015).”
• Autophagy and Tumor Metabolism (2017, background): “…significant selectivity for cargo and there are multiple selective autophagy pathways that are named for the particular cargo that is degraded (e.g. mitochondria – mitophagy; ferritin – ferritinophagy; ER – reticulophagy; bacteria – xenophagy) (Khaminets et al., 2016; Mancias and Kimmelman, 2016).”
• APP mouse models for Alzheimer's disease preclinical studies (2017, neutral): “Recent studies on the ubiquitin-proteasome system and autophagy (Nilsson et al , 2013; Ciechanover & Kwon, 2015; Khaminets et al , 2016) point to the essential significance of protein degradation in many diseases including AD.”
• Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor (2016, neutral): “Mitophagy Involves Sequential Events at the Outer and Inner Mitochondrial Membranes Several proteins on the OMM directly bind LC3, serving as mitophagy receptors, or indirectly bind LC3 when ubiquitinated via adaptor proteins that contain both ubiquitin binding association (UBA) domains and LIR doma”
• Mechanisms of Selective Autophagy (2016, neutral): “receptors bind their cargos directly, in mammalian cells several receptor proteins recognize poly-ubiquitin chains attached to the surface of cargos for selective autophagy [11].”
• Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, neutral): “…for proteins that act as autophagy receptors, SQSTM1/p62 (Fecto et al., 2011), OPTN (Maruyama et al., 2010) and Ubiquilin 2 (Williams et al., 2012), which enhance the incorporation of autophagy substrates into autophagosomes via interactions with LC3, as discussed above (Khaminets et al., 2016).”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Thus, attempts have been made to explore targeted inhibitors for E2, E3 ligases, the UBL system and the process of UBD binding to Ub.(504,505) However, most of these inhibitors work well in cell culture studies and not well enough in animal models and clinical trials.”
• Molecular definitions of autophagy and related processes (2017, neutral): “Many macroautophagy receptors also contain ubiquitin-binding domains, allowing them to recruit ubiquitinated substrates to forming autophagosomes (Khaminets et al , 2016).”