Autophagy and Tumor Metabolism
By Alec C. Kimmelman, E. White. Cell Metabolism, 2017
745 citations recorded by the source corpus.
Autophagy is a critical cellular process that generally protects cells and organisms from stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy plays a role in pathological processes such as cancer. Indeed, there has been substantial work exploring the complex and context-dependent role of autophagy in cancer. One of the emerging themes is that in certain cancer types, autophagy is important to support tumor growth and therefore inhibiting autophagy as a therapeutic approach is actively being tested in clinical trials. A key mechanism of how autophagy promotes the growth and survival of various cancers is its ability to support cellular metabolism. The diverse metabolic fuel sources that can be produced by autophagy provides tumors with metabolic plasticity and can allow them to thrive in what can be an austere microenvironment. Therefore, understanding how autophagy can fuel cellular metabolism will enable more effective combinatorial therapeutic strategies.
Subfields: Epidemiology, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/5724f4e1484b94ca3fa63560f4590d9183f45c06
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
In Molecular Biology
In Pharmacology
Citations in the corpus
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “Autophagy is a catabolic process of macromolecules (proteins, lipids) and organelles whereby intracellular components are enveloped in double-membrane vesicles, known as autophagosomes, which ultimately fuse with lysosomes where the content is degraded and recycled into the cytosol (121).”
- Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “In the presence of lysosomal hydrolases, cargoes are degraded, and nutrients are recycled.(62) The dysregulation of autophagy contributes to tumor growth and progression.”
- Targeting autophagy in cancer (2018, methodology): “through nutrient transporters and used to fuel growth of the cell.(22)”
- Molecular mechanisms of cell death in neurological diseases (2021, background): “ongoing controversy about the role of autophagy in glioblastoma (and many other cancers for that matter [101]),”