Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels

By D. Prati, E. Taioli, A. Zanella, E. Torre, S. Butelli, E. Del Vecchio, L. Vianello, F. Zanuso, F. Mozzi, S. Milani and 3 more. Annals of Internal Medicine, 2002

1,482 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/4d001c77c2c4ccadc40153114c1511462c70eddc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. C. Day
2. S. Bellentani
3. V. Ratziu
4. H. Cortez‐Pinto
5. J. Clark
6. A. Diehl
7. Giulio Marchesini
8. J. Browning

In Hepatology

1. J. Clark
2. C. Day
3. A. Diehl
4. M. H. Murad
5. S. Bellentani

In Pathology and Forensic Medicine

1. J. Clark
2. C. Day
3. M. H. Murad
4. S. Bellentani

Citations in the corpus

• AASLD Guidelines for Treatment of Chronic Hepatitis B (2015, background): “It is recognized that the normal ALT levels of healthy adults are 30 U/L for males and 19 U/L for females.(19) Thus, using these ALT cutoffs for normal, the recommendation to consider treatment of adults with ALT values of 2 times the ULN (>60 U/L for males and >38 U/L for females) is more inclusive”
• A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “However, in patients with IR and increased ALT [142], the prevalence of NASH and advanced fibrosis [21] may be higher than in the overall obese or diabetic population.”
• Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance (2018, background): “The upper limits of normal (ULN) for ALT in healthy adults are reported to be 29-33 U/L for males and 19-25 U/L for females.((94-96)) For purposes of guiding management of CHB, a ULN for ALT of 35 U/L for males and 25 U/L for females is recommended (Fig.”
• Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. (2005, methodology): “Alcohol use was estimated on the basis of answers to a validated set of questions from the 1995 National Alcohol Survey (34).”
• The prevalence and etiology of elevated aminotransferase levels in the United States (2003, background): “(29) suggests that updated so-called “healthy ranges” for ALT (upper limit of normal of 19 IU/L in women and 30 IU/L in men) are indicated to improve the sensitivity of ALT for chronic liver disease.”
• Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes (2008, neutral): “03 Metabolic syndrome 86 (19) 12 (19) 83 (21) NS”