Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes

By A. Fracanzani, L. N. Valenti, E. Bugianesi, M. Andreoletti, A. Colli, E. Vanni, C. Bertelli, E. Fatta, D. Bignamini, Giulio Marchesini and 1 more. Hepatology, 2008

676 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/324f462ef6a1e024d999ff1518b899daa3ddc341

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. C. Day
2. S. Bellentani

In Epidemiology

1. C. Day
2. S. Bellentani
3. V. Ratziu
4. H. Cortez‐Pinto
5. Giulio Marchesini

In Hepatology

1. C. Day
2. S. Bellentani

Citations in the corpus

• Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, neutral): “The real prevalence is unknown since NAFLD is often undiagnosed and most subjects with NAFLD, even those with diabetes, have normal liver aminotransferases and clinicians do not suspect the potential presence of NAFLD [5–7].”
• The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. (2013, result): “The lack of change seen in the liver function tests may have been a result of the small sample size or the short duration of the study; however, it does demonstrate a lack of sensitivity of these tools as markers of liver inflammation, as it has been previously demonstrated [44,45].”
• A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “Advanced fibrosis can coexist with normal aminotransferases [43,44].”
• Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus (2016, neutral): “Moreover, in studies involving liver biopsy, about 30% to 50% of patients have steatohepatitis even in the presence of normal plasma aminotransferase levels (9, 14, 21, 48).”