The prevalence and etiology of elevated aminotransferase levels in the United States

By J. Clark, F. Brancati, A. Diehl. American Journal of Gastroenterology, 2003

1,413 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/63c6d7ff190ad899a50329f0e92cf169c689299b

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1. Z. Younossi
2. M. Ekstedt
3. V. Basevi
4. G. Vernon
5. J. Ong
6. Ruben Hernaez
7. A. Diehl
8. E. Bugianesi

Citations in the corpus

• Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. (2013, background): “A number of prior studies have estimated the prevalence of NAFLD in the United States (7–9), including 1 study by our group (6).”
• Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss (2022, background): “The World Health Organization Global Health Observatory data in 2014 indicates that globally obesity occurs in 15% of women and 11% of men aged 18 and over [8, 9].”
• Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity (2004, background): “*Subjects meeting 3 or more of the following criteria: (1) waist circumference 102 cm in men or 88 cm in women; (2) fasting triglyceride 150 mg/dL; (3) fasting HDL 40 mg/dL in men or 50 mg/dL in women; (4) blood pressure 130/85 mm Hg or a diagnosis of hypertension; (5) fasting glucose 110 mg/dL or a”
• Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults (2011, background): “In addition to these rates, the prevalence of elevated ALT levels observed in other studies ranged from 8% to 9%.(20)”
• The Epidemiology of Nonalcoholic Fatty Liver Disease in Adults (2006, background): “31 IU in women and negative testing for hepatitis B and C, a transferrin saturation ,50%, and average use of alcohol of ,2 drinks/day for men and ,1 drink/day for women.(21) Elevations of aminotransferases were found in 8% of the population, of which 31% had an identifiable cause.”
• INCREASED FRUCTOSE CONSUMPTION IS ASSOCIATED WITH FIBROSIS SEVERITY IN PATIENTS WITH NAFLD (2010, background): “T he prevalence of obesity in the United States is rising, and with it, the frequency of fatty liver, nonalcoholic steatohepatitis (NASH), ‘‘cryptogenic’’ cirrhosis, hepatocellular carcinoma, and other end-organ complications of the metabolic syndrome.(1,2) The healthcare burden and associated econo”
• Molecular mediators of hepatic steatosis and liver injury. (2004, unknown): “NAFLD is the most frequent cause of abnormal liver function tests (LFTs) in the US (2, 3), affecting approximately 30 million Americans.”