Aging and proinflammatory cytokines

By H. Bruunsgaard, Maria Pedersen, B. K. Pedersen. Current opinion in hematology, 2001

710 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/4cffe5a9b695bf8eb6ae3f6c6071448b564fb468

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Xia Zhang
2. Wei-Wei Chen
3. Wenjuan Huang
4. J. Campisi
5. J. Pickup
6. G. Hotamisligil
7. K. Wellen

In Immunology

1. J. Campisi
2. C. Patil
3. F. Rodier
4. Xia Zhang
5. Wei-Wei Chen
6. S. Iyer
7. Wenjuan Huang
8. V. Appay

In Physiology

1. J. Campisi
2. C. Patil
3. F. Rodier
4. P. Desprez
5. Jean-Philippe Coppé
6. Denise P. Muñoz
7. J. Goldstein
8. Xia Zhang

Citations in the corpus

• Role of neuroinflammation in neurodegenerative diseases (Review) (2016, positive): “Normal aging is associated with an increase in the expression level of systemic inflammatory factors (36) such as pro‑inflammatory cytokines (37‑39).”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “TNFα, IL-1β and IL-6 are thought to play a significant role in the process of ageing and are actually also found at higher concentrations in the blood of the elderly [112,113].”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “age-associated pathology or reflects the sum of ongoing pathological processes((173,194)) remains uncertain.”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “In humans, IL-1 , IL-6, and TNF- are generally higher in the plasma of older individuals compared with their young counterparts (10, 37, 54, 61, 70, 202).”
• Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor (2008, background): “Whatever the case, there is mounting evidence that senescent cells increase with age [65–68] and that chronic inflammation is a prominent feature of aging [69].”
• Neuroinflammation Induces Neurodegeneration (2016, background): “This chronic increase of inflammatory mediator levels in the elderly people make them more prone to neuroinflammation in the CNS leading to the onset of neurodegenerative diseases [6,26,28].”
• Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. (2004, background): “Similarly, fatigue and alterations in sleep patterns, which are symptoms well known in the diabetic clinic, are linked with insulin resistance and elevated blood IL-6 and TNF- (independently of obesity) (1,135,136).”