Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.

By J. Jacobi, Gilles L. Fraser, D. Coursin, R. Riker, D. Fontaine, Eric T. Wittbrodt, Donald B Chalfin, Michael F Masica, H. Bjerke, William M. Coplin and 8 more. Critical Care Medicine, 2002

1,935 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine

View Paper: https://www.semanticscholar.org/paper/4cf9e29adb791e29873cb4374ca7b55f35350174

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In Anesthesiology and Pain Medicine

In Critical Care and Intensive Care Medicine

Citations in the corpus

Sedation and analgesia in the mechanically ventilated patient. (2012, background): “To choose an optimal strategy of medication use, it is necessary to understand the body of literature that forms the groundwork for evidence-based recommendations (1).”
Posttraumatic Stress Disorder in General Intensive Care Unit Survivors: A Systematic Review (2008, background): “We note that some form/level of sedation is required for mechanically ventilated patients, not just for humane practice but also to reduce oxygen demands and promote synchronous breathing with ventilators [40].”
Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients (2006, methodology): “At our institution, sedatives and analgesic medications were prescribed by physicians according to a protocol adapted from the guidelines of the Society of Critical Care Medicine.(16) The medications were titrated by the bedside nurses to achieve a target sedation level determined by the treating te”
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). (2003, methodology): “Objective, goaldirected sedation therapy is now the recommended standard to avoid oversedation and to promote earlier extubation.(2,8,14,17-19) As pointed out by others,(1,20-22) very few of the available sedation scales have been appropriately tested for reliability and validity.”
Costs associated with delirium in mechanically ventilated patients* (2004, background): “The strengths of this study include the prospective use of valid and reliable measures of levels of arousal and delirium that were specifically designed for mechanically ventilated patients and that are recommended for routine use in the ICU (47).”
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. (2004, background): “We have found during a year-long implementation study incorporating more than 22000 patient observations that nursing staff readily incorporated such measurements into routine care,67 in keeping with recently issued guidelines of the Society of Critical Care Medicine.18 Perhaps the greatest benefit ”
Current Practices in Sedation and Analgesia for Mechanically Ventilated Critically Ill Patients: A Prospective Multicenter Patient-based Study (2007, background): “Of the 1,405 patients registered in the database, 24 were excluded because they had a severe brain injury on admission (11), no mechanical ventilation (5), or a delay in the mechanical ventilation use exceeding 24 h after admission (8).”
A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. (2006, methodology): “* The use of sedatives was calculated as midazolam-equivalent (34), and the use of opioids as fentanyl-equivalent (35).”
Recommendations for end-of-life care in the intensive care unit: A consensus statement by the American College of Critical Care Medicine (2008, background): “Haloperidol reaches maximal effect approximately 25–30 mins following an intravenous dose and can be repeated every 15–30 mins as needed (82).”
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (2007, background): “Duration of brain organ dysfunction, d Delirium-free and coma-freeb 7 (1-10) 3 (1-6) .”
Sedation in the intensive care setting (2012, neutral): “Thereafter, objective routine assessments of pain, arousal, and acute brain dysfunction (eg, delirium and coma) are necessary to guide the adjustment of goal-directed therapeutic targets that change with the medical condition of the patient.(1)”