Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

By Pratik Pandharipande, B. Pun, Daniel L. Herr, M. Maze, Timothy D. Girard, Russell R. Miller, Ayumi K. Shintani, Jennifer L. Thompson, James C. Jackson, Stephen A. Deppen and 4 more. Journal of the American Medical Association (JAMA), 2007

1,294 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/491a4d45d78cef57627e9d7c76a38e39dfb27c2c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Anesthesiology and Pain Medicine

1. Mayur B. Patel
2. E. W. Ely
3. A. Marra
4. Shruti B. Patel
5. J. Kress
6. Pratik Pandharipande

In Critical Care and Intensive Care Medicine

1. Pratik Pandharipande
2. J. Kress
3. Mayur B. Patel
4. E. W. Ely
5. A. Marra
6. Shruti B. Patel
7. B. Pun
8. Dimitry S. Davydow

In Pulmonary and Respiratory Medicine

1. E. W. Ely
2. B. Pun
3. J. Kress
4. Pratik Pandharipande

Citations in the corpus

• Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine (2017, background): “[62] in 106 mechanically ventilated patients, showed that continuous use of dexmedetomidine for up to 5 days resulted in more comaand/or delirium-free days compared with lorazepam infusion.”
• The ABCDEF Bundle in Critical Care (2017, background): “The MENDS study (Maximizing Efficacy of Targeted Sedation and Reducing Neurologic Dysfunction) evaluated the role of changing sedation paradigms on acute brain dysfunction, comparing dexmedetomidine with lorazepam.(31) The dexmedetomidine sedative strategy resulted in more days alive without”
• Posttraumatic Stress Disorder in General Intensive Care Unit Survivors: A Systematic Review (2008, background): “, via use of alternative sedatives [39] – would have important longer-term mental health benefits.”
• Sedation and analgesia in the mechanically ventilated patient. (2012, background): “(85) 106 med–surg pts on MV Dexmedetomidine vs.”
• Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit (2013, methodology): “ICU team practices affect the incidence of delirium and its consequences (220, 222, 329-333).”