Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients

By Pratik Pandharipande, Ayumi Shintani, J. Peterson, B. Pun, G. Wilkinson, Robert S. Dittus, Gordon R. Bernard, E. W. Ely. Anesthesiology, 2006

1,099 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Critical Care and Intensive Care Medicine, Epidemiology

View Paper: https://www.semanticscholar.org/paper/0cd86a8a635fbcfbc35071d806701480fa79608c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Anesthesiology and Pain Medicine

1. S. Mcgrane
2. Mayur B. Patel
3. E. W. Ely
4. A. Marra
5. Shruti B. Patel
6. Christopher G Hughes
7. J. Kress
8. Pratik Pandharipande

In Critical Care and Intensive Care Medicine

1. Pratik Pandharipande
2. S. Mcgrane
3. Christopher G Hughes
4. J. Kress
5. D. Needham
6. Mayur B. Patel
7. E. W. Ely
8. A. Marra

In Epidemiology

1. Pratik Pandharipande

Citations in the corpus

• Long-term complications of critical care (2011, background): “, anxious patients receive more sedation) or if they truly cause psychiatric symptoms, possibly through their effect on ICU delirium (79, 82, 90, 97, 98).”
• Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (2007, background): “Outcome Received study drug, d 5 (2-6) 4 (2-6) .”
• Sedation and analgesia in the mechanically ventilated patient. (2012, background): “There is a high incidence of delirium with benzodiazepines used in ICU patients (56).”
• Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit (2013, background): “ICU team practices affect the incidence of delirium and its consequences (220, 222, 329-333).”
• Sedation in the intensive care setting (2012, positive): “Brain dysfunction and sedation Associations between benzodiazepines and worse brain dysfunction outcomes have been found in medical, surgical, trauma, and burn ICU cohorts.(4,20,21) As noted earlier, data on the effects of opioid analgesia are not consistent.”
• The ABCDEF Bundle in Critical Care (2017, background): “003).(28) Similarly Seymour and colleagues(29) confirmed that benzodiazepines are an independent risk factor for development of delirium during critical illness even when given more than 8 hours before a delirium assessment.”
• Chronic critical illness. (2010, background): “Extrapolation from the acute ICU setting suggests that, because of their deliriogenic potential (58, 59), benzodiazepines should be avoided as possible.”