Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
By Magalie Rocheville, D. Lange, U. Kumar, Shutish C. Patel, R. Patel, Y. Patel. Science, 2000
889 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4c9db03a02fd4fc1174c97717d6417d6efeb2b16
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In Cellular and Molecular Neuroscience
- Michel Bouvier
- Jeremy K. Seamans
- B. Bettler
- Michael J Frank
- Torben Ott
- Andreas Nieder
- Brian K. Kobilka
- Randall C. O’Reilly
In Molecular Biology
Citations in the corpus
- Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. (2002, background): “In another study, coexpression of the D2 dopamine receptor with the 1318 SSTR5, which can bind somatostatin but cannot signal, imparts somatostatininduced cAMP inhibition (31).”
- Oligomerization of G-protein-coupled transmitter receptors (2001, background): “Both BRET and FRET efficacy vary with the sixth power of the distance between the the heterodimerization of the D2 and SSTR5 receptors, Rocheville et al.(81) found that FRET between D2 and SSTR5 fluorescently labelled antibodies could be observed only in the presence of either somatostatin or dopami”
- Molecular Structure and Physiological Functions of GABAB Receptors (2004, background): “There are now several examples where even distantly related GPCRs form heteromeric complexes (1, 117, 164, 284).”
- Roles of G‐protein‐coupled receptor dimerization (2004, background): “Whereas several studies suggest that ligand binding can regulate the dimer by either promoting (Rodriguez-Frade et al, 1999; Angers et al, 2000; Rocheville et al, 2000a,b; Cornea et al, 2001; Horvat et al, 2001; Kroeger et al, 2001; Wurch et al, 2001; Patel et al, 2002; Zhu et al, 2002;…”
- Dopamine Receptor Signaling (2004, background): “The formation of heteromers can be constitutive (252) or stimulated by the binding of ligands, particularly agonists (250), and may underlie mutually inhibitory (253) or stimulatory (250) interactions.”