Cell culture: Biology's new dimension

By A. Abbott. Nature, 2003

1,256 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/4c9b7eed54038fac08573a317a313bff3629ec92

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In Biomedical Engineering

In Cell Biology

Citations in the corpus

Spheroid-based drug screen: considerations and practical approach (2009, background): “This trend has been illustrated, among others, in Alison Abbott's 2003 Nature report entitled 'Cell culture: biology's new dimension', which particularly emphasized the basic necessity for such systems before turning to whole-animal studies, for both basic research and therapeutic developmen”
Recent advances in three‐dimensional multicellular spheroid culture for biomedical research (2008, background): “As a result, loss of tissue-specific properties is common for cells grown in 2-D monolayer cultures [1–3].”
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation (2012, background): “Standard two-dimensional cell cultures for testing effects of anticancer agents are simple and convenient, but present significant limitations in reproducing the complexity and pathophysiology of in vivo tumor tissue [2-8].”
Three-Dimensional Cell Culture: A Breakthrough in Vivo (2015, background): “It is important that the culture environment takes into account the spatial organization of the cell [3–5].”
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. (2010, background): “Landmark 3D cancer studies are in line with this observation and demonstrated that phenotypical differences between normal and malignant epithelial breast cells were observed exclusively in 3D [2,15,30].”
Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties (2018, background): “It is known that the cell phenotype, as well as cell functions and metabolic processes, is largely determined by the complex system of cell interactions with other cells and the surrounding extracellular matrix [107].”