Barrel-stave model or toroidal model? A case study on melittin pores.

By Lin F. Yang, T. Harroun, T. Weiss, Lai Ding, Huey W. Huang. Biophysical Journal, 2001

1,030 citations recorded by the source corpus.

Subfields: Biomaterials, Insect Science, Microbiology

View Paper: https://www.semanticscholar.org/paper/4c6e489d5920e2e0d32a374038956e8287961cec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

Citations in the corpus

Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics (2011, background): “Depending on their structure, they can form either proteinaceous or lipidic pores (Yang et al., 2001).”
Mechanisms of Antimicrobial Peptide Action and Resistance (2003, background): “More recent studies often support the toroid pore model (see below; Yang et al., 2000, 2001).”
Mechanisms of action of Bcl-2 family proteins. (2013, background): “Amphipathic a-helical peptides can porate membranes via two separate mechanisms termed barrel-stave or toroidal, leading to two distinct pores, proteinaceous or lipidic, respectively (Yang et al. 2001).”
Antimicrobial peptides: The ancient arm of the human immune system (2010, background): “Thus, the pore is lined by both the peptides and the lipid headgroups.(7) The mechanism of a number of AMPs may be described by a third model, known as the carpet model, which is characterized by the peptides remaining in a parallel orientation to the membrane surface covering it in a carpet-like ma”
Peptide Antimicrobial Agents (2006, neutral): “pore include the magainins, melittin, and LL-37 (85, 98, 162, 267).”
Antimicrobial peptides: an overview of a promising class of therapeutics (2007, background): “More recent studies often support the toroidal pore model [56, 58].”
Melittin: a Membrane-active Peptide with Diverse Functions (2007, background): “In addition, melittin is a potent inhibitor of Ca2+-ATPase (Voss et al. 1991; Mahaney and Thomas, 1991), H+K+-ATPase (Cuppoletti et al. 1989; Cuppoletti, 1990) and Na+K+-ATPase (Cuppoletti and Abbott, 1990).”
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? (2005, background): “At low peptide/lipid ratios, peptides are bound parallel to a lipid bilaye”
The Roles of Antimicrobial Peptides in Innate Host Defense (2009, methodology): “The toroidal pore model differs from the barrel stave model in that the peptides are always associated with the lipid head groups even when perpendicularly inserted into the lipid bilayers [81].”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “Initially cationic AMPs were believed to act only by disrupting the integrity of the bacterial membrane as described through one of four proposed models: barrel-stave [20], aggregate [114], carpet and toroidal pore [33, 63, 86, 113, 118], resulting in the formation of a transient channel, micellariz”