Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

By K. Brogden. Nature Reviews Microbiology, 2005

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How researchers see this paper

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Antimicrobial peptides: The ancient arm of the human immune system (2010, background): “2).(5) The barrel-stave model is based on the assumption that hydrophobic peptide regions align with the acyl chains of the membrane lipids, while the hydrophilic peptide regions form the inner surface of the pore channel.”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “Increasing evidence demonstrates that AMPs have multiple targets within the cell [11, 23].”
Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides (2013, background): “AMPs may interact with intracellular targets, binding to DNA, RNA and protein, or even interfering with the characterized FtsZ gene, responsible for bacterial cell division septum or with protein synthesis such as DNA gyrase and DnaK (Brogden, 2005; Chauhan et al., 2006; Handler et al., 2008; Maróti”
Antimicrobial Peptides (2013, background): “Instead of directly interacting with the membrane, these AMPs kill bacteria by inhibiting some important pathways inside the cell such as DNA replication and protein synthesis [83].”
Acinetobacter baumannii: Emergence of a Successful Pathogen (2008, background): “Justifiably, significant attention is being directed toward eukaryotic antimicrobial peptides, which are ubiquitous elements of the innate immune response in a variety of invertebrate, plant, and animal species (64).”