The spindle assembly checkpoint.
By Pablo Lara-Gonzalez, Frederick G. Westhorpe, Stephen S. Taylor. Current Biology, 2012
913 citations recorded by the source corpus.
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint network, which in turn blocks cell cycle progression. Once all kinetochores become stably attached to the spindle, the checkpoint is inactivated, which alleviates the cell cycle block and thus allows chromosome segregation and cell division to proceed. Here we review recent progress in our understanding of how the checkpoint signal is generated, how it blocks cell cycle progression and how it is extinguished.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/acc9f8e0ca9bb7eacf56158dec3699ff2fab151c
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Citations in the corpus
- Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events (2014, background): “Partial Cdk1 inhibition from G 2 induces premature cytokinesis despite an active SAC During mitosis the SAC delays mitotic exit until all chromosomes are correctly attached to opposing spindle poles and aligned on the metaphase plate.(5,24) The continued presence of Plk1 at kinetochores in cells att”
- Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling (2013, background): “The kinetochore levels of SAC proteins are dynamically regulated during the process of attachment of kinetochores to microtubules, with maximal levels being reached at unattached kinetochores and minimal levels being reached at metaphase (Lara-Gonzalez et al., 2012; Foley and Kapoor, 2013).”
- How Taxol/paclitaxel kills cancer cells (2014, background): “Unattached kinetochores, which have not made stable attachments to microtubules, activate a signal transduction cascade that delays mitotic progression by inhibiting the anaphasepromoting complex/cyclosome (Kops et al., 2005; Lara-Gonzalez et al., 2012; Foley and Kapoor, 2013).”