The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
By Y. Omatsu, Tatsuki Sugiyama, H. Kohara, G. Kondoh, N. Fujii, K. Kohno, T. Nagasawa. Immunity, 2010
821 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Hematology
View Paper: https://www.semanticscholar.org/paper/4c1e919f6dccca53b5f0058f91aad9e1fbe991f6
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In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- Mesenchymal stromal cells: new directions. (2012, background): “However, short-term ablation of CAR cells in vivo impaired the ability of BM cells to undergo adipogenic and osteogenic differentiation (Omatsu et al., 2010).”
- Arteriolar niches maintain haematopoietic stem cell quiescence (2013, neutral): “…factors is not specific to osteoblasts and other studies have found that most BM HSCs are found near sinusoidal endothelial cells 18 , and perivascular stromal cells including, CXCL12-abundant reticular (CAR) cells 19,20 , Nestin + mesenchymal stem cells 21 or Leptin receptor (LepR) + cells 22 .”
- Leptin Receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow (2014, positive): “Consistent with the conclusion that MSCs secrete factors that promote HSCmaintenance (Méndez-Ferrer et al., 2010; Omatsu et al., 2010; Sacchetti et al., 2007), both Scf-GFP bone marrow cells and Cxcl12-DsRed bone marrow cells were highly enriched for CFU-Fs (Figures 2B and 2C).”
- Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011, background): “Recent studies have suggested that a more primitive precursor of osteoblasts compose the stem cell niche (Méndez-Ferrer et al., 2010b; Omatsu et al., 2010).”
- Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “The induced deletion of either CAR cells or CXCR4 reduces the number of HSCs in the bone marrow by 50% (7).”
- Rhythmic modulation of the hematopoietic niche through neutrophil clearance (2013, background): “Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation.”