Toll-like receptors: linking innate and adaptive immunity.

By Chandrashekhar Pasare, R. Medzhitov. Microbes and infection, 2004

817 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/4c13c52f2a6a37d8f811e78110cd587fb7f4010c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. H. Hemmi
2. R. Medzhitov
3. Noah W. Palm
4. R. Steinman
5. David Mackey
6. A. Bent
7. T. Boller
8. Shizuo Akira

In Microbiology

1. David Mackey
2. R. Steinman
3. A. Bent
4. H. Hemmi
5. R. Medzhitov

Citations in the corpus

• Dendritic cells: translating innate to adaptive immunity. (2006, background): “, T-helper type 1 (Th1) vs Th2 types of CD4+ T cell responses [1–3].”
• The sea urchin immune system (2006, background): “recognize molecular pathogen signatures (Pasare and Medzhitov, 2005), and cytoplasmic TIR (Toll-IL1 receptor) domains, which are important for signalling.”
• Aspects of immune dysfunction in end-stage renal disease. (2008, background): “Because TLRs are thought to link the innate and adaptive immunity (6), their role will be described separately.”
• Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. (2006, background): “Furthermore, TLR signaling influences phagocytosis and triggers adaptive immunity (Pasare and Medzhitov 2004; Underhill and Ganter 2004).”
• Elicitors, effectors, and R genes: the new paradigm and a lifetime supply of questions. (2007, background): “In Drosophila, the Toll receptor controls embryonic development and then later controls innate immunity responses in the same animal (134).”
• Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation (2010, neutral): “activation of innate host defense (1, 2).”
• Pattern recognition receptors and control of adaptive immunity (2009, background): “TLRs have also been shown to be critical for the induction of adaptive immunity in response to various immunizations and infections (20, 23).”
• The Role of Inflammation and Infection in Preterm Birth (2007, background): “The ligand for TLR-5 is flagellin.(15,139,140) Ligation of TLRs results in activation of nuclear factor kappa B, which in turn leads to the production of cytokines, chemokines, and antimicrobial peptides.”