Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function.

By L. Fialkow, Yingchun Wang, G. Downey. Free Radical Biology & Medicine, 2007

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Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? (2016, background): “During inflammatory process the activated phagocytic cells like neutrophils and macrophages produce large amounts of ROS and reactive nitrogen and chlorine species including superoxide, hydrogen peroxide, hydroxyl free radical, nitric oxide, peroxynitrite, and hypochlorous acid to kill the invading ”
Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “In the innate immune system, macrophages play a pivotal role in eliminating the pathogen through the generation of reactive oxygen species including superoxide, nitric oxide, hydrogen peroxide, hydroxyl radical, peroxynitrite and hydrochlorous acid (Hocl) [22].”
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration (2008, background): “At inflamed sites, neutrophils deploy a potent antimicrobial arsenal that includes proteinases, antimicrobial peptides and RO”