Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

By Mikhail V. Semenov, K. Tamai, B. Brott, Michael Kühl, S. Sokol, Xi He. Current Biology, 2001

730 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4bc9f3016351ce03199c281c3e87774954e5b09a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Nusse
2. Christof Niehrs
3. Hans Clevers

In Molecular Biology

1. Hans Clevers
2. Christof Niehrs
3. R. Nusse
4. Xi He
5. K. Tamai
6. C. Logan
7. A. Gregorieff
8. H. Begthel

Citations in the corpus

• Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling (2009, background): “Dkk1 antagonism on Wnt/b-catenin signaling was identified originally through its binding with Lrp6.((35,36)) Sclerostin bound to both Lrp5 and Lrp6, and particularly, it was”
• Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. (2004, background): “Consistent with this notion, LRP5 has been shown to interact with different Wnt/frizzled complexes (Tamai et al. 2000; Semënov et al. 2001; Kato et al. 2002; Caricasole et al. 2003), although the binding sites have not been determined.”
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “Dkk1 disrupts the FzLrp5/Lrp6 complex formation induced by Wnt1 in vitro (Semenov et al., 2001), suggesting that Dkk1 inhibits Wnt ignaling by preventing Fz-Lrp5/Lrp6 complex formation.”
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, background): “, which prevents the formation of the ternary complex between WNT, FZ and LRP and, consequently, activation of the pathwa”
• Secreted antagonists of the Wnt signalling pathway (2003, background): “However, unlike sFRPs, Dkk-1 prevents activation of the Wnt signalling pathway by binding to LRP5/6 rather than to Wnt proteins (Bafico et al., 2001; Mao, B. et al., 2001; Semenov et al., 2001).”
• The Wnt signaling pathway in development and disease. (2004, background): “It binds to LRP with high affinity (Bafico et al. 2001, Mao et al. 2001a, Semenov et al. 2001) and to another class of transmembrane molecules, the Kremens (Mao & Niehrs 2003, Mao et al. 2002).”
• Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. (2003, background): “…1996; Fodde et al. 2001) as well as adenomatous polyp formation in the mouse intestine (Moser et al. 1990; Fodde et al. 1994; Oshima et al. 1995; Shibata et al. 1997), whereas mutation of Tcf4 leads to the depletion of intestinal proliferative compartments in fetal mice (Korinek et al. 1998).”
• Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling (2002, background): “Dkk1 has been shown to inhibit Wnt signalling by binding to and antagonizing LRP5/”
• Secreted and transmembrane wnt inhibitors and activators. (2013, background): “2002; Mao and Niehrs 2003), and mutation of the conserved Cys-220 of the colipase fold abolishes the interaction (Semenov et al. 2001).”