Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.
By Hyun Jung Kim, D. Huh, Geraldine Hamilton, D. Ingber. Lab on a Chip, 2012
942 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Oncology
View Paper: https://www.semanticscholar.org/paper/4bbe9cfeda749f811508a4f3ef48e8d6ec1849ba
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
- Ali Khademhosseini
- Yu Shrike Zhang
- Mehmet Remzi Dokmeci
- Safa A. Damiati
- James J. Hickman
- Severine Vermeire
- U. Kompella
- Rimantas Kodzius
In Oncology
Citations in the corpus
- The intestinal barrier: a fundamental role in health and disease (2017, positive): “Previous work with a human gut-on-a-chip model showed that Caco-2 cells formed functional cells from different lineages, and a high integrity barrier with better characteristics than the static transwell models [52].”
- Microfluidic 3D cell culture: from tools to tissue models. (2015, positive): “Although typically associated with 2D cell culture, membranes are also widely used in microfluidic chips [14].”
- Organ-on-a-Chip Platforms for Studying Drug Delivery Systems (2014, positive): “The system geometry and structures recreate physiological length scales, concentration gradients, and the fluid flow generates mechanical forces that recapitulate the in vivo microenvironment experienced by cells [13,55].”
- The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “726 Several microfluidics-based “gut on a chip” systems provide increasingly better approximations 727 of the human intestinal environment (Kim et al., 2012; Marzorati et al., 2014; Shah et al., 2016).”
- TEER measurement techniques for in vitro barrier model systems (2015, positive): “Those microfabricated systems that are designed for TEER measurements, however, can offer TEER data in addition to permeability coefficients.(78) With the system developed by Kim et al.”
- Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “…et al., 2013), the bone-marrow (Cui et al., 2007), the skin and hair (Ataç et al., 2013) and the intestine (Esch et al., 2012; Kim and Ingber, 2013; Kim et al., 2012, 2013a; Kimura et al., 2008; Lahar et al., 2011; Mahler et al., 2009a; McAuliffe et al., 2008; Ootani et al., 2010; tute for…”