A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

By Xinwei Cao, T. Sūdhof. Science, 2001

1,152 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4b4d18404990535e252688305e8365e33204d59e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Neelroop Parikshak
2. E. Mandelkow
3. E. Thies
4. Thomas Gonatopoulos-Pournatzis
5. Michael J.E. Sternberg
6. Rudolph E. Tanzi
7. Manuel Irimia
8. Frederick P. Roth

In Physiology

1. E. Mandelkow
2. Philip C. Wong
3. E. Thies
4. Richard O'Brien
5. Rudolph E. Tanzi
6. Christian Haass
7. Daniel H. Geschwind
8. Sangram S. Sisodia

Citations in the corpus

• Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “…γ -secretase cleavage of CTF α produces the more benign p3 fragment instead of A β . γ -Secretase cleavage of either membrane bound CTF also generates a cytosolic element, AICD (A β PP intracellular domain, sometimes referred to as CTF γ ) , which may play a role in signal transduction [10–13].”
• Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. (2004, background): “…levels of the intracellular do-Columbia University mains of Notch and APP, which can function as tran-New York, New York 10032 scriptional activators (Cao and Sudhof, 2001; Moehl-6 Nathan Kline Institute mann et al., 2002; Schroeter et al., 2003; Song et al.,Orangeburg, New York 10962 1999).”
• Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease (2018, background): “In addition, sAPPα is involved in neurite outgrowth and has a neuroprotective effect (Baratchi et al., 2012), and AICD is involved in signal transduction (Cao and Sudhof, 2001).”
• Picomolar amyloid-β positively modulates synaptic plasticity and memory in hippocampus (2008, background): “…1994; Furukawa et al., 1996; Ishida et al., 1997; Meziane et al., 1998), and the intracellular CTF may regulate gene transcription, calcium signaling, synaptic plasticity, and memory (Cao and Südhof, 2001; Gao and Pimplikar, 2001; Kimberly et al., 2001; Leissring et al., 2002; Ma et al., 2007).”
• Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress (2002, background): “This may simply happen in response to an adverse cellular environment or a consequence of a possible transcription factor activity of the cleaved COOH-terminal stub of APP (as proposed recently [Cao and Sudhof, 2001]).”
• Alzheimer's disease: the cholesterol connection (2003, background): “APP's cytoplasmic domain has been shown to interact with several cytosolic adaptor proteins and can function as a signaling molecul”