Molecular pathology of malignant gliomas.

By D. Louis. Annual Review of Pathology, 2006

679 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “Three GBM samples containing the highest Igf2 concentrations (605.8 ng/ml, Neuron 69, 893–905, March 10, 2011 ª2011 Elsevier Inc. 899 Figure 5.”
Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy (2011, neutral): “Glioma is the most common primary intracranial tumor in humans 38 .”
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (2009, background): “The most significantly downregulated gene in GNS cells relative to fetal NS cells is the well-studied tumor suppressor PTEN, which is often lost or mutated in gliomas and other cancers (Louis, 2006).”
Integrating diverse genomic data using gene sets (2011, background): “Necrosis and hypoxia are pathognomonic features of the highest-grade malignant gliomas and are thought to play a key role in the aggressive behavior of GBM, including invasiveness and chemo-resistance, through a variety of mechanisms [15-17].”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “The most important characteristics used for glioma grading and GBM diagnostics are microvascular proliferation, which is associated with reorganization of the extracellular matrix (ECM), and high proliferative capacity in the tumor cells (40).”