Neuronal 'On' and 'Off' signals control microglia.

By K. Biber, H. Neumann, Kazuhide Inoue, H. Boddeke. Trends in Neurosciences, 2007

784 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Oncology

View Paper: https://www.semanticscholar.org/paper/4aad9a84545ebe92f5e50566126be1ffa1670258

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. B. Barres
2. Beth Stevens
3. Guo-Yuan Yang
4. Yongting Wang
5. Jixian Wang
6. Yuanyuan Ma
7. R. Ransohoff
8. Berislav Zlokovic

In Neurology

1. B. Barres
2. Beth Stevens
3. R. Ransohoff
4. Guo-Yuan Yang
5. Yongting Wang
6. Jixian Wang
7. Yuanyuan Ma
8. A. Stephan

In Oncology

1. Guo-Yuan Yang
2. Yongting Wang
3. Jixian Wang
4. Yuanyuan Ma
5. B. Barres
6. R. Ransohoff

Citations in the corpus

• Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals (2009, background): “…substantial activation in response to these pathological states results in a transformation into an “amoeboid” morphology, migration toward the site of injury and release of various neuroactive compounds to ultimately result in neurotoxicity or neuroprotection (Vilhardt, 2005; Biber et al., 2007).”
• The biphasic function of microglia in ischemic stroke (2017, positive): “‘Off’ signal mainly occurs in the healthy brain and is mediated by release of CX3CL1, CD22, neurotransmitters and neurotrophins from neurons, which could bind with receptors on microglia and help microglia exert physiological function (Biber et al., 2007).”
• Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “Reduced production by neurons of compounds that keep microglia in relative quiescence under normal conditions (CD200 and fractalkine) (black arrows) also contributes to microglial activation.”
• Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner (2012, positive): “…work has demonstrated that microglia have the capacity to interact with synaptic elements in response to neurotransmitter release and/or sensory experience (Biber et al., 2007; Fontainhas et al., 2011; Nimmerjahn et al., 2005; Ransohoff and Perry, 2009; Tremblay et al., 2010a; Wake et al., 2009).”
• iPSC-derived human microglia-like cells to study neurological diseases (2017, neutral): “Overall, these results implicate both soluble and surface CNS cues as factors in microglia maturation (Biber et al., 2007) (Figure 5E, GO Terms, Figure S6).”
• Microglia: new roles for the synaptic stripper. (2013, neutral): “Another classification distinguishes between ‘‘on signaling,’’ which includes factors newly appearing in the pathologic context or are upregulated and ‘‘off signaling,’’ which includes factors that disappear or are downregulated in pathology (Biber et al., 2007).”
• The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “In this context it is of particular interest that neuronal activity can regulate the surface expression of the other class of MHCs, MHC-II, specifically on microglia (Neumann et al. 1998, Biber et al. 2007).”