The RNAi revolution

By C. Novina, Phillip A. Sharp. Nature, 2004

730 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4a9a81df8b3a6c3dcb66b5c8ef417051a4f294ff

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In Molecular Biology

1. Bryan R. Cullen
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4. Yan Zeng
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Citations in the corpus

• A combinatorial library of lipid-like materials for delivery of RNAi therapeutics (2008, background): “dtd" [ ]> The specific reduction, or silencing, of gene expression through RNAi has considerable potential to create a new class of therapeutics that addresses previously untreatable disease”
• Inhibition of respiratory viruses by nasally administered siRNA (2005, background): “Faced with these barriers to the traditional anti-viral strategies, we tested RNA”
• Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing? (2019, background): “The antisense siRNA strand guides RISC to the target mRNA for degradation or translational repression (Fig. 1A; Hannon, 2002; Novina and Sharp, 2004; Carthew and Sontheimer, 2009; Rao et al., 2009; Wilson and Doudna, 2013; Housden et al., 2017).”
• DNA methylation and human disease (2005, background): “Further interest in this area comes from important new evidence that concerns the regulation of DNA methylation, indicating interactions between DNA methylation and the histone modification machinery, and showing a potential role of small RNA”
• Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. (2005, background): “RNAi occurs in a variety of evolutionarily diverse organisms (Novina and Sharp, 2004).”
• MicroRNA biogenesis and cancer. (2005, background): “For the few miRNAs whose function has been uncovered, they are important regulators of various aspects of developmental control in both plants and animals (1, 2). In the few years since the inception of this regulatory RNA phenomenon, much progress has been made towards an understanding of the mecha”
• Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs (2004, methodology): “jpg" NDATA ITEM> ]> RNAi has been applied widely as a target validation tool in post-genomic research, and it represents a potential strategy for in vivo target validation and therapeutic product developmen”
• Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha (2005, background): “…to be appreciated, it is generally believed that miRNAs regulate gene expression at the post-transcriptional level by inhibiting the expression of mRNAs bearing fully or partly homologous target sequences (Carrington and Ambros, 2003; Bartel, 2004; He and Hannon, 2004; Novina and Sharp, 2004).”
• Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 (2005, neutral): “dtd" [ ]> The process of post-transcriptional double-stranded (ds)RNA-dependent gene silencing is commonly referred to as RNA interference (RNAi”