Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

By M. Lachner, D. O’Carroll, S. Rea, K. Mechtler, T. Jenuwein. Nature, 2001

2,999 citations recorded by the source corpus.

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Citations in the corpus

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. (2001, background): “The binding is highly specific because a K9-methylated H3 peptide, but not a K4-methylated peptide displaced HP1 and, importantly, other chromodomain-containing proteins, including SUV39H1 and Mi-2, failed to bind to methylated H3-K9 peptide.”
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, background): “…missegregation, and male meiotic defects (Peters et al., 2001b). cific; neither the chromo domain of Polycomb nor the chromo shadow domain of HP1 shows this interactionFurther, the Suv39h1/SUV39H1 proteins are found in association with M31 (Aagaard et al., 1999), a mouse (Lachner et al., 2001).”
The nucleosome: from genomic organization to genomic regulation. (2004, background): “With regard to ubiquitination, one lysine residue at the C terminus of both histones H2A andproteins related to heterochromatin protein HP1 (Jacobs et al., 2001; Lachner et al., 2001; Bannister et al., 2001).”
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions (2006, neutral): “Dimethylation of H3-K9, which is thought to mediate repression of transcriptio”
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase (2002, background): “For instance, the chromo domain of HP1 has been shown to specifically bind methylated H3 Lys 9, and this binding is essential for heterochromatin formation in vivo”
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. (2012, positive): “It is generally assumed that this triggers the modification of neighboring nucleosomes and results in spreading of the chromatin mark (Bannister et al., 2001; Lachner et al., 2001).”
Vernalization requires epigenetic silencing of FLC by histone methylation (2004, background): “Methylated K9 of histone H3 triggers the binding of HETEROCHROMATIN PROTEIN 1, leading to heterochromatin formation and silencin”