Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

By K. Hanaoka, F. Qian, A. Boletta, A. Bhunia, K. Piontek, L. Tsiokas, V. Sukhatme, W. Guggino, G. Germino. Nature, 2000

830 citations recorded by the source corpus.

Subfields: Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/49c9784f807f8321af7acddc7daa99a27056127f

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In Genetics

1. P. Beales
2. N. Katsanis
3. C. Montell

Citations in the corpus

• Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut (2005, background): “In zebrafish, charon, an inhibitor of nodal signaling, is expressed in the tailbud at 2-3 SS during the formation of KV and then symmetrically adjacent to KV until the 14 SS (Hashimoto et al., 2004).”
• Calcium absorption across epithelia. (2005, background): “PKD1 is a very large protein of 12 TM segments, whereas PKD2 has the predicted topology of the TRP channel consisting of 6 TM spanning domains and clearly conduct ions (156).”
• The ciliopathies: an emerging class of human genetic disorders. (2006, background): “The products of these two genes are polycystin 1 and 2, respectively, two novel proteins able to interact with each other (112, 130) and thought to be part of a Ca2+ channel localized in the primary cilium of renal epithelial cells (31, 34, 106, 123, 142).”
• TRP channels as cellular sensors (2003, background): “TRPP1 is not known to form a channel by itself, but it complexes with TRPP2 to form a Ca 2p -permeable nonselective cation channe”
• The TRP Superfamily of Cation Channels (2005, background): “However, coexpression of TRPP1 along with TRPP2 induces translocation of TRPP2 to the plasma membrane and production of a Ca2+-permeable nonselective cation conductance (213).”
• An introduction to TRP channels. (2006, background): “In heteromeric complexes with TRPP2 (previously termed PKD2), PKD1 is reported to form a Ca2+-permeable nonselective cation channel with a linear I-V relation (175).”
• TRP channel proteins and signal transduction. (2002, background): “Coexpression of PKD1 and PKD2 in CHO cells generated time-dependent outwardly rectifying current that was 20-fold larger than in mock transfected cells (54).”
• TRP Channels (2012, neutral): “TRPP1 contains a N-terminal ER retention signal that locks the channel in intracellular compartments (136,199,436).”