Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

By Chester A. Mathis, Yanming Wang, D. Holt, Guo-feng Huang, M. Debnath, William E. Klunk. Journal of Medicinal Chemistry, 2003

978 citations recorded by the source corpus.

Subfields: Biochemistry, Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/499310e707c93cf2a359a8074615d820a7e88620

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Citations in the corpus

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “…brain energy metabolism (de Leon et al., 1983; Minoshima et al., 1997; Small et al., 1995), amyloid-related pathology (Jack et al., 2008; Klunk et al., 2004; Mathis et al., 2003), and the function of certain neural circuits (Kuhl et al., 1996; Nikolaus et al., 2009; Scheltens and Korf, 2000).”
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. (2009, methodology): “PIB was synthesized at this facility using a previously published protocol (Mathis et al., 2003).”
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. (2006, methodology): “The finding that certain benzothiazol derivatives bind to amyloid with high affinity and cross the brain–blood barrier (BBB) led to the development of N-methyl[(11)C]2-(40-methylaminophenyl)-6hydroxy-benzothiazole (PIB) (Klunk et al., 2001; Mathis et al., 2002; Wang et al., 2002; Mathis et al., 2003”
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B (2005, methodology): “The radiosynthesis of PIB was initially performed (n ¼ 7) as previously described (Mathis et al, 2003).”
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer’s Disease (2009, methodology): “Procedures for PiB–PET imaging have been described previously (Mathis et al., 2003; Klunk et al., 2004; Bacskai et al., 2007; Johnson et al., 2007).”
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans (2006, methodology): “Pittsburgh Compound-B Synthesis and Positron Emission Tomography Imaging PIB was synthesized according to published methods.(11) PET imaging was performed using a Siemens 961 HR ECAT PET scanner (CTI, Knoxville, TN).”
APOE Predicts Aβ but not Tau Alzheimer’s Pathology in Cognitively Normal Aging (2010, methodology): “The cerebellum was chosen as the reference region because there is little specific binding of PIB in postmortem samples of cerebellar cortex even among those with AD at autopsy.(62) The Logan analysis yields a tracer distribution volume ratio (DVratio), which was then converted to an estimate of the”
PET Imaging of Tau Deposition in the Aging Human Brain (2016, neutral): “[11C] Pittsburgh-B (PiB) was synthesized at the Lawrence Berkeley National Laboratory (LBNL) Biomedical Isotope Facility (BIF), using a protocol described in detail previously (Mathis et al., 2003).”