MDC1 is a mediator of the mammalian DNA damage checkpoint

By G. Stewart, Bin Wang, C. Bignell, A. Taylor, Stephen J. Elledge. Nature, 2003

952 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/48ffc60e99ce1929af9d3627c648e8f094449dc5

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In Molecular Biology

1. J. Bartek
2. J. Lukas
3. Yves Pommier
4. L. Zou
5. Alexandre Maréchal
6. P. Jeggo
7. Stephen P. Jackson
8. M. Löbrich

In Oncology

1. J. Bartek
2. J. Lukas
3. P. Jeggo
4. Yves Pommier
5. M. Löbrich
6. L. Zou
7. Alexandre Maréchal
8. C. Lukas

Citations in the corpus

• Living on a break: cellular senescence as a DNA-damage response (2008, background): “Crucial to the establishment of this positive feedback loop are mediator of DNA-damage checkpoint 1 ( MDC1”
• DNA damage sensing by the ATM and ATR kinases. (2013, background): “Through its BRCT domains, Mdc1 directly binds to phosphorylated H2AX (known asgH2AX) and is required for full-sized gH2AX foci formation (Stewart et al. 2003; Lee et al. 2005; Stucki et al. 2005).”
• γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “While 53BP1 can be targeted to damaged chromatin by the above mechanism, its efficient accumulation and sustained retention withinDSB-containing chromatin requires g-H2AX andMDC1 (64,65,72,77,83).”
• Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage (2005, background): “MDC1 silencing has been demonstrated to abrogate the phosphorylation of H2AX as well as BRCA1, DNA-PK, and Chk1 and the formation of foci containing Nbs1, 53BP1, and BRCA1 (42, 43, 61).”
• Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1 (2021, background): “However, subsequent studies demonstrated that γH2AX is a direct participant in recruitment of repair factors, and interacts directly with MDC1 [7]; via specific binding of its C-terminal”
• Pathways of apoptotic and non-apoptotic death in tumour cells (2004, background): “Cells that lack MDC1 are sensitive to ionizing radiation and show a G2-checkpoint defec”