Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

By A. Festa, R. D'Agostino, G. Howard, L. Mykkänen, R. Tracy, S. Haffner. Circulation, 2000

2,583 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/48daa1bb5ccee76fe7b0af6b9d669f07f657550d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. P. Ridker
2. J. Pickup
3. N. Rifai
4. Z. Bloomgarden
5. Michael R. Irwin
6. JoAnn E. Manson
7. B. K. Pedersen
8. S. Grundy

In Epidemiology

1. P. Ridker
2. J. Pickup
3. N. Rifai
4. JoAnn E. Manson
5. M. Stern
6. Z. Bloomgarden
7. Michael R. Irwin
8. J. Petrie

In Pulmonary and Respiratory Medicine

1. J. Pickup
2. P. Ridker
3. B. K. Pedersen

Citations in the corpus

• C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. (2001, background): “In this regard, substantial experimental evidence and more recent crosssectional data suggest that interleukin 6 (IL-6) and C-reactive protein (CRP), 2 sensitive physiological markers of subclinical systemic inflammation, are associated with hyperglycemia, insulin resistance, and overt type 2 DM.(8-”
• Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. (2002, background): “Finally, it is possible that the detrimental effect of IR on CVD might operate through a mechanism of chronic subclinical inflammation (40,41).”
• Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology (2008, neutral): “suggested that therapeutics aimed at reducing CRP levels should be developed to prevent and/or treat these conditions [58–63].”
• 10-year research update review: the epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden. (2005, methodology): “Statistical methods are being developed for optimally combining data from multiple informants (Kraemer et al., 2003) and across studies (Festa et al., 2000).”
• Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. (2006, background): “Small elevations in circulating inflammatory mediators, for example, have been associated with the syndrome of insulin resistance and type 2 diabetes mellitus, independent of adiposity.(27) Moreover, a shorter sleep duration,(28) as well as sleep deprivation(29) and cumulative partial sleep loss,(30”
• Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. (2002, background): “High CRP correlates with endothelial dysfunction (37, 38) and impaired insulin sensitivity (39, 40) in nonpregnant populations and predicts risk for type 2 diabetes in women (14).”