New insights into the multidimensional concept of macrophage ontogeny, activation and function

By Florent Ginhoux, Joachim L. Schultze, P. Murray, J. Ochando, Subhra K. Biswas. Nature Immunology, 2015

728 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/48b4e3a056299dd11c43745b728b99fcdd240d35

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Citations in the corpus

Macrophage Polarization. (2017, background): “Single cell techniques and new tools are, however, advancing the understanding of polarization heterogeneity at a rapid rate (1).”
Wound healing: cellular mechanisms and pathological outcomes (2020, background): “However, this dichotomous classification has become outdated, with both human [34] and murine [35] macrophages now known to showdiverse transcriptional andphenotypic responses to different stimuli (reviewed in [36]).”
Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “To answer these questions we will require high-resolution markers of cellular origin and improved genetic tools to dissect the function of tissue-resident and inflammatory macrophages as discussed recently (Ginhoux et al., 2015).”
Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species (2019, background): “This is most appreciated for macrophages; recently, the field has championed a more holistic analysis of these cells by considering their ontogeny, their response to environmental signals, and their transcriptional state (Ginhoux et al., 2016; Mantovani et al., 2017).”
The microenvironmental landscape of brain tumors (2017, background): “Whether this also applies to patients with non-small-cell lung cancer, the most frequent source of brain metastases, is now under active investigation, and early results have been promising (Dudnik et al., 2016; Goldberg et al., 2016).”
The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, background): “Given that IL4 is a known mediator of alternative activation associated with a wound-healing phenotype in macrophages (20, 29), and the role of TGFb1 during wound-healing and tissue turnover in multiple contexts (30, 31), these results were consistent with our observation of glial scarring in associ”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Circulating monocytes contribute to forming the skin tissue monocyte-macrophage population [61].”