Mitochondrial reactive oxygen species drive proinflammatory cytokine production

By Edwina Naik, V. Dixit. Journal of Experimental Medicine, 2011

742 citations recorded by the source corpus.

Recent work indicates that mitochondrial ROS act via several pathways to elicit proinflammatory cytokines in human and mouse cells.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/48a45730e032e4e4fb488fc23614ca03d73b472c

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Citations in the corpus

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes (2012, background): “Thus, ROS produced by mitochondria play a role in the upregulation of inflammatory responses by acting as signal-transducing molecules (37).”
Integrating mechanisms of pulmonary fibrosis (2011, background): “Indeed, activation of the Nalp3 inflammasome and IL-1 secretion are largely driven by reactive oxygen species (ROS) derived by ROS-generating mitochondria (Naik and Dixit, 2011; Zhou et al., 2011) and NADPH oxidase (NOX) family members expressed in macrophages and neutrophils (Cassel et al.”
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “Thus, mitophagy is an important negative regulator of the inflammasome, and inhibition of autophagy results in accumulation of damaged mitochondria and intracellular mtROS, release of mtDNA and activation of the inflammasome [149].”
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Further, mitochondrial ROS play a major role in inducing chronic inflammation and cancer (4, 149, 225, 324).”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “This can lead to multiple functional outcomes such as activation of redox-sensitive transcription factors (such as HIF-1a and NF-jB) (60, 269, 435), activation of pro-inflammatory cytokines, and activation of inflammasomes (185, 308).”
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “ROS impair cells function not only by reacting with nucleic acids, proteins, and lipids but also by inducing production of proinflammatory cytokine [206] and angiogenic signals [207].”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…inducing the generation of neutrophil extracellular traps (NETs), and stimulating the production of the pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and macrophage inflammatory protein 2 (MIP-2) (Brinkmann et al., 2010; Naik and Dixit, 2011; Sheshachalam et al., 2014).”