High-efficiency TALEN-based gene editing produces disease-resistant rice

By Tingyu Li, Bo Liu, M. Spalding, D. Weeks, Bing Yang. Nature Biotechnology, 2012

1,039 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/48a367b6735bacdb47c578cce32b938473f331c8

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Citations in the corpus

The Sequence of 1504 Mutants in the Model Rice Variety Kitaake Facilitates Rapid Functional Genomic Studies (2017, methodology): “, 2013a), TALEN-based gene editing (Moscou and Bogdanove, 2009; Li et al., 2012), CRISPR/Cas9 genome editing (Jiang et al.”
Genome Editing—Principles and Applications for Functional Genomics Research and Crop Improvement (2017, background): “…Arabidopsis, rice, Brachypodium, barley, maize, tobacco, soybean, wheat, tomato, potato and sugarcane (Cermak et al., 2011; Mahfouz et al., 2011; Li et al., 2012a; Li et al., 2012b; Christian et al., 2013; Shan et al., 2013b; Wendt et al., 2013; Zhang et al., 2013; Haun et al., 2014; Liang et…”
The CRISPR/Cas9 system for plant genome editing and beyond. (2015, background): “…under the current guidelines), there is hope and confidence that plants altered by the excision of a few nucleotides using genome editing tools such as CRISPR/Cas9 would not be classified as genetically modified organisms (Hartung and Schiemann, 2014; Li et al., 2012; Podevin et al., 2013).”
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice (2013, background): “Because endonucleases such as TALENs have been shown to be effective in causing site-specific DSBs and subsequent genetic mutations in rice (23,45), we also tested whether the Cas9/sgRNA system was able to induce DNA alterations in rice cells.”
Genome Editing of Plants (2017, background): “An example of this was demonstrated in rice in order to create a rice variety resistant to the bacterial pathogen, Xanthomonas oryzae, the causal agent of a debilitating blight (Li et al., 2012).”
TALENs: a widely applicable technology for targeted genome editing (2012, positive): “To date, TALENs have been used to make knockout mutations in Arabidopsis 15 and to introduce resistance to infection by Xanthomonas bacteria in rice by disrupting the target sites of naturally occurring TALEs that contribute to pathogenicity 16 .”
Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922 (2016, background): “In rice, the disease-susceptibility gene and the sucrose efflux transporter gene OsSWEET14, which aids in pathogen survival and virulence, was mutated by TALENs to produce disease-resistant rice with normal phenotypes [56]; moreover, using TALENs to target the OsBADH2 gene produced a generation of f”