Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions
By O. Felfoul, M. Mohammadi, S. Taherkhani, Dominic de Lanauze, Y. Xu, Dumitru Loghin, Sherief Essa, S. Jančík, D. Houle, M. Lafleur and 9 more. Nature Nanotechnology, 2016
935 citations recorded by the source corpus.
Oxygen depleted hypoxic regions in the tumour are generally resistant to therapies1. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour2 of magnetotactic bacteria3, Magnetococcus marinus strain MC-14, can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals5, tend to swim along local magnetic field lines and towards low oxygen concentrations6 based on a two-state aerotactic sensing system2. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in SCID Beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
Subfields: Condensed Matter Physics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2bb406fef6f3efae3e6aeff84b0f4020644fe92a
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In Condensed Matter Physics
In Molecular Biology
- Wei Gao
- Liangfang Zhang
- Metin Sitti
- Victor Sourjik
- Joseph Wang
- Serge Cosnier
- Parikha Mehrotra
- E. Paleček
Citations in the corpus
- Artificial Intelligence in Medicine: 16th Conference on Artificial Intelligence in Medicine, AIME 2017, Vienna, Austria, June 21-24, 2017, Proceedings (2017, positive): “Early data have disclosed a significant increase in the gradient of desired drug into the hypoxic zones [17].”
- Micro/Nanorobots for Biomedicine: Delivery, Surgery, Sensing, and Detoxification (2017, background): “Magneto-aerotactic bacteria were able to migrate into tumour hypoxic regions under a focalized directional magnetic field of only 15 G (37).”
- Soft erythrocyte-based bacterial microswimmers for cargo delivery (2018, methodology): “Although high-throughput fabrication and magnetic steering of biohybrid microswimmers have been previously shown (1, 12, 16), the RBC microswimmer design described here combines these features with additional advanced functionalities, including active deformation of the soft cargo and on-demand term”