Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.

By I. Xynos, A. Edgar, L. Buttery, L. Hench, Julia M. Polak. Biochemical and Biophysical Research Communications - BBRC, 2000

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Review of bioactive glass: from Hench to hybrids. (2013, background): “Extracellular matrix secretion was also increased, which mineralized without addition of supplements [118,119].”
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. (2006, background): “The released ions induce intracellular and extracellular responses [91,100].”
Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering (2010, background): “Recent studies have shown that bioactive (partially) resorbable glasses and their ionic dissolution products enhance osteogenesis by regulating osteoblast proliferation, differentiation, and gene expression [7,41,51,191-198].”
Sol-gel based materials for biomedical applications (2016, neutral): “repair mechanism for tissue regeneration [368,369].”
The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. (2010, background): “This has been previously shown in primary human osteoblasts treated with 45S5 Bioglass dissolved in DMEM, which showed increased proliferation compared to controls [22].”