The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro.
By E. Gentleman, Yann C. Fredholm, G. Jell, N. Lotfibakhshaiesh, M. O'Donnell, R. Hill, Molly M. Stevens. Biomaterials, 2010
616 citations recorded by the source corpus.
Bioactive glasses (BG) which contain strontium have the potential to combine the known bone regenerative properties of BG with the anabolic and anti-catabolic effects of strontium cations. Here we created a BG series (SiO(2)-P(2)O(5)-Na(2)O-CaO) in which 0-100% of the calcium was substituted by strontium and tested their effects on osteoblasts and osteoclasts in vitro. We show that ions released from strontium-substituted BG enhance metabolic activity in osteoblasts. They also inhibit osteoclast activity by both reducing tartrate resistant acid phosphatase activity and inhibiting resorption of calcium phosphate films in a dose-dependent manner. Additionally, osteoblasts cultured in contact with BG show increased proliferation and alkaline phosphatase activity with increasing strontium substitution, while osteoclasts adopt typical resorption morphologies. These results suggest that similarly to the osteoporosis drug strontium ranelate, strontium-substituted BG may promote an anabolic effect on osteoblasts and an anti-catabolic effect on osteoclasts. These effects, when combined with the advantages of BG such as controlled ion release and delivery versatility, may make strontium-substituted BG an effective biomaterial choice for a range of bone regeneration therapies.
Subfields: Biomedical Engineering, Oral Surgery, Orthopedics and Sports Medicine
View Paper: https://www.semanticscholar.org/paper/4ebdbeeeefec47b0e7901f7e9fff47374debd726
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In Biomedical Engineering
In Oral Surgery
In Orthopedics and Sports Medicine
Citations in the corpus
- Review of bioactive glass: from Hench to hybrids. (2013, background): “may be an effective way to deliver a steady supply of strontium ions to a bone defect site for osteoporotic patients [305].”
- Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering (2010, background): “Other bioactive glass compositions developed over the years contain no sodium or have additional elements incorporated in the silicate network such as fluorine [13], magnesium [14,15], strontium [16-18], iron [19], silver [20-23], boron [24-27], potassium [28] or zinc [29,30].”