Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering

By L. Gerhardt, Aldo R. Boccaccini. Materials, 2010

1,062 citations recorded by the source corpus.

Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

Subfields: Biomedical Engineering, Oral Surgery, Surgery

View Paper: https://www.semanticscholar.org/paper/1b53d3f57d89a1447cf290789537ab03c0a21c4a

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In Biomedical Engineering

Citations in the corpus

Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs (2019, background): “BaG has been a traditional material for reconstructing bone defects [106,107].”
Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions (2015, background): “For many applications, especially in the area of bone tissue engineering, this scaffold will be fabricated from an inorganic ceramic or glass [1].”