The Role of DNA Methylation in Mammalian Epigenetics

By Peter A. Jones, Daiya Takai. Science, 2001

2,054 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4713ac9828e0cee2a28df34e3a52abadf0afb577

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Citations in the corpus

Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “DNA methylation of CpG is important for long-term gene silencing [150].”
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. (2007, background): “High concentrations of these CpG dinucleotides, called CpG islands (Gardiner-Garden & Frommer, 1987), can be found most often at promoter regions and first exons but may also occur in regions more toward the 3′ end (Bird, 1980; Larsen et al., 1992; Jones & Takai, 2001; Rountree et al., 2001).”
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. (2004, neutral): “6 65/M AML 1 41 0 5/ 7 5 10 CR 7 18 11 31/M AML 2 16 3 t(3;3) 10 10 CR 21 62 20 55/F AML 1 11 0 Diploid 15 10 HI 4 29 41 77/M AML 1 35 2 Diploid 15 10 HI 4 43 44 78/M AML 2 8 2 Diploid 15 10 HI 2 44 16 65/M AML 1 60 3 7 15 10 CR 17 35 19 48/F AML 3 72 4 Diploid 15 10 CR 7 47 50 27/F AML 4 5 0 Diploi”
Evolution of dioecy and sex chromosomes via methylation driving Muller's ratchet (2003, neutral): “…Force et al., 1999), all of which result in disproportionate methylation (Nagl & Ehrendorfer, 1974; Volpe & Eremenko, 1974; Holliday, 1984; Yoder, Walsh & Bestor, 1997; Matzke & Matzke, 1998; Regev, Lamb & Jablonka, 1998; Colot & Rossignol, 1999; Jones & Takai, 2001; Martienssen & Colot, 2001).”
Parasite Manipulation of Host Behavior: An Update and Frequently Asked Questions (2010, neutral): “The process of genetic suppression is generally the outcomeofDNAmethylation or histone acetylation, both molecular mechanisms that mediate these phenomena (Jaenisch and Bird, 2003; Jones and Takai, 2001; Richards, 2006).”
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. (2004, background): “This methylation of cytosine is associated with gene silencing, and genes with abundant 5-methylcytosine in their promoter region are usually transcriptionally silent (2).”
The evolution of transcriptional regulation in eukaryotes. (2003, background): “Proteins bound to these sites produce a scalar response, the frequency with which new transcripts are initiated (Latchman 1998; Davidson 2001; Locker 2001).”
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, background): “…and maintaining epigenetic expressionAn interesting recent finding has been the identifica- tion of histone H3 methylated at lysine 9 (H3-mLys9) as states, not only in heterochromatin but in silenced euchromatic domains (Jones and Takai, 2001; Martienssencharacteristic of the heterochromatic state.”