Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

By C. Carrieri, L. Cimatti, M. Biagioli, Anne Beugnet, S. Zucchelli, Stefania Fedele, E. Pesce, I. Ferrer, Licio Collavin, C. Santoro and 5 more. Nature, 2012

929 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/471100bcf00b4a461019596c2aaecf9e88d5fb6c

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Citations in the corpus

Revealing protein–lncRNA interaction (2015, background): “Moreover, they can bind antisense mRNAs and regulate them post-transcriptionally [11], or function as scaffold for the assembly of macromolecular complexes [12].”
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “…of lncRNAs have been characterized functionally, and most of them are shown to control gene expression by regulating various aspects of gene expression (Ankö and Neugebauer, 2010; Carrieri et al., 2012; Gong and Maquat, 2011; Hung et al., 2011; Lee, 2012; Wang et al., 2011; Yoon et al., 2012).”
Long Non-coding RNAs in the Cytoplasm (2016, background): “an embedded inverted SINEB2 repetitive element (Figure 1B) [45].”
FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome (2017, background): “FEELncclassifier also annotates 5006 lncRNAs in the ‘antisense exonic’ class as potential candidates for complementary interactions with the mRNA transcribed in opposite direction (55,56).”
Long noncoding RNAs: Cellular address codes in development and disease (2013, positive): “Other SINEB2-containing antisense lncRNAs may function in a similar way (Carrieri et al., 2012) (Figure 4C).”
Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs (2013, background): “It was also shown recently that a B2 SINE embedded in a mouse lncRNA antisense to Uchl1 is required for post-transcriptional up-regulation of UCHL1 protein synthesis, an activity that can be transferred to an artificial antisense green fluorescent protein transcript containing the B2 SINE element [1”
The rise of regulatory RNA (2014, background): “A substantial proportion of lncRNAs reside within, or are dynamically shuttled, to the cytoplasm indicating roles in other cellular processes, including the regulation of protein localization 293 , mRNA translation 294 and mRNA stability 295 .”
LncRNA-mediated regulation of cell signaling in cancer (2017, background): “For instance, lncRNA antisense (Uchl1) promotes UCHL1 protein synthesis by enhancing the interaction of the 5′ overlapping sense protein-coding mRNA with active polysomes (Carrieri et al 2012).”