Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease

By E. Ryu, H. Harding, J. Angelastro, O. Vitolo, D. Ron, L. Greene. Journal of Neuroscience, 2002

597 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/46c620591c9075162690a7a3235a3ac76d770320

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Citations in the corpus

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. (2008, background): “The islet in T2DM has parallels with the neuropathology in neurodegenerative diseases such as Alzheimer’s disease (24–27), Parkinson’s disease (28, 29), prion encephalopathy (30), amyotrophic lateral sclerosis (31), and Huntington’s disease (32) (Table 1).”
A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. (2005, background): “The concept of reinforcer is strictly behavioral and makes no reference to subjective or cognitive states.”
Endoplasmic reticulum stress signaling in disease. (2006, background): “This drug, which is commonly used as a model for Parkinson’s disease since it selectively kills dopaminergic neurons in vivo, causes ER stress in dopaminergic neurons in tissue culture (71, 162).”
ER stress and neurodegenerative diseases (2006, background): “Recent studies with cultured neuronal cells, including dopaminergic neurons, showed that these compounds trigger ER stress and induce a number of genes.36,37 Gene profiling revealed that both ER chaperones and other components of the UPR such as the transcription factor, CHOP/Gadd153 were upregulate”
Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. (2005, background): “When PC12 cells were exposed to 100 M 6-hydroxydopamine for 8 h, they responded by an upregulation of the expression of numerous genes indicative of UPR (550).”
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities (2008, background): “Neurons from PERK −/− embryos display increased sensitivity to 6-hydroxydopamin”
Roles of CHOP/GADD153 in endoplasmic reticulum stress (2004, background): “the CHOP gene prevents neuronal cells from MPTP-induced apoptosis.(102) Several lines of evidence suggested a link between dysfunction of the ERAD system and the pathogen-”
Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Supporting evidences from in vitro models of Parkinson’s disease show that 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP+) (Parkinson mimetic drugs) trigger ER stress in dopaminergic neurons [261, 262].”